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Vaginal Cream


Symptoms it treats

Vaginal dryness and irritation



Vaginal creams are used to treat vaginal symptoms associated with menopause, like vaginal dryness and irritation. An applicator is used to dispense the medication inside the vagina. This is a good option for women who are primarily concerned with vaginal menopause symptoms.




Apply once daily

FDA Approved?


How it works

Vaginal creams are used to treat vaginal symptoms of menopause. The estrogen hormones are delivered locally, meaning they do not enter your bloodstream to treat other non-vaginal symptoms of menopause (like hot flashes).

Most vaginal creams come pre-loaded in an applicator that you insert into your vagina. Once the applicator is high in your vagina, you push the applicator to dispense the medication.

Vaginal creams are applied once daily, but some doctors recommend that you use the cream for the first 2-3 weeks a month so your body can take a break in between!


Generic names


  • Estradiol

  • Estropipate
  • Conjugated estrogens

Common brands


  • Estrace

  • Ogen

  • Premarin

Common side effects for the hormone patch

1. Headaches

2. Vaginal spotting

3. Bloating

4. Stomach cramps

5. Painful or tender breasts

6. Hair loss

7. Yeast infection

8. Fluid retention

9. Nausea and/or vomiting


​We do not recommend you use hormones if you have any of the following:

  • Unusual vaginal bleeding

  • Personal history of certain cancers such as breast cancer or uterine cancer

  • Personal history of blood clots in the legs or lungs

  • Bleeding disorder

  • History of stroke or heart attack

  • Liver problems

  • Serious reactions to estrogen medicines

Some antibiotics and medications may make this treatment less effective, make sure you inform your doctor about all of the medications you are taking. If you have a uterus you may have a higher risk of developing endometrial cancer after 1 year of taking estrogen-only medication. Talk to your doctor about other medicines you can take to protect yourself.

Want more information?

Preparing yourself for menopause can be overwhelming, but we are here to help! Visit our blog for general menopause education, information about your menopause symptoms, and stories from women like you.