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Hormone Spray


Symptoms it treats

1. Hot flashes (all brands)

2. Night sweats (all brands)

3. Vaginal dryness and irritation (all brands)



Hormone sprays are used to treat menopause symptoms by spraying estrogen medication on the skin. This is a good option for women who want to take hormones topically (through the skin). There is currently one FDA approved spray.




Apply once to three times daily

FDA Approved?


How it works

Hormone sprays work by delivering hormones through the skin. When starting this treatment, it is recommended to first start with one spray and then work up to three sprays.

Helpful tips:

  • Spray on non-overlapping skin on your arm, starting with your forearm near your elbow.

  • Allow for an hour for the spray to absorb into the skin.

Generic names


  • Estradiol

Common brands


  • Evamist

Common side effects for the hormone patch

1. Headaches

2. Vaginal spotting

3. Bloating

4. Stomach cramps

5. Painful or tender breasts

6. Hair loss

7. Yeast infection

8. Redness around the patch

9. Fluid retention

10. Nausea and/or vomiting

11. Stuffy or dry nose and sneezing


​We do not recommend you use hormonal products if you have any of the following:

  • Unusual vaginal bleeding

  • Personal history of certain cancers such as breast cancer or uterine cancer

  • Personal history of blood clots in the legs or lungs

  • Bleeding disorder

  • History of stroke or heart attack

  • Liver problems

  • Serious reactions to estrogen medicines

Some antibiotics and medications may make the spray less effective, make sure you inform your doctor about all of the medications you are taking. If you have a uterus you may have a higher risk of developing endometrial cancer after 1 year of taking estrogen-only medication. Talk to your doctor about other medicines you can take to protect yourself.

Want more information?

Preparing yourself for menopause can be overwhelming, but we are here to help! Visit our blog for general menopause education, information about your menopause symptoms, and stories from women like you.